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Therapeutic vaccine candidates applying viral vectors encoding LMP2 have productively induced virus-distinct CD8⁺ T cell responses in early-section medical trials. On top of that, adoptive T mobile therapies like posoleucel also target LMP2 along with other latency proteins such as EBNA1, reinforcing its importance as being a conserved and immunodominant antigen.
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Peptide Swimming pools can be used to encourage antigen-specific CD4+ and CD8+ T cells. The activated T cells can then be detected, quantified or isolated for analysis determined by produced cytokines and upregulated activation markers.